Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential response to amphetamine in schizophrenia.

Z Cesarec, A K Nyman

    Acta Psychiatrica Scandinavica
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Predicting long-term outcome in schizophrenia.

    Acta psychiatrica Scandinavica·1991
    Same author

    The concept of cycloid psychosis: sensitivity and specificity of syndromes derived by multivariate clustering techniques.

    Acta psychiatrica Scandinavica·1991
    Same author

    Differentiation and prediction in schizophrenia using the metacontrast technique.

    Acta psychiatrica Scandinavica·1989
    Same author

    Nonregressive schizophrenia--a long-term comparative follow-up investigation.

    Acta psychiatrica Scandinavica·1989
    Same author

    Attempt at predicting paraphrenic outcome in young, first admitted schizophrenic patients.

    Psychopathology·1987
    Same author

    Non-regressive schizophrenia: prediction of regressive course.

    Acta psychiatrica Scandinavica·1986

    Adding amphetamine to neuroleptic maintenance therapy improved work capacity in chronic schizophrenia patients. Symptom type influenced response, suggesting varied dopaminergic sensitivity in schizophrenia.

    Area of Science:

    • Psychiatry
    • Neuroscience
    • Pharmacology

    Background:

    • Chronic schizophrenia often leads to long-term work incapacity.
    • Neuroleptic drugs are standard maintenance therapy.
    • The role of dopaminergic stimulation in schizophrenia symptoms is debated.

    Purpose of the Study:

    • To investigate the efficacy of amphetamine augmentation in neuroleptic-treated chronic schizophrenic patients.
    • To explore the relationship between schizophrenic symptomatology and response to amphetamine.
    • To examine autonomic functioning and attention in relation to amphetamine response.

    Main Methods:

    • A cohort of 48 chronic schizophrenic patients receiving maintenance neuroleptic therapy was studied.
    • Amphetamine was added to therapy, and patients were monitored for changes in symptoms and work efficiency.

    Related Experiment Videos

  • Experimental withdrawal of amphetamine was performed.
  • Autonomic functioning (skin conductance) and attention tests were conducted on a sub-sample.

    • Main Results:

    • Amphetamine improved complaints and work efficiency in 32 of 48 patients.
    • Gains were lost upon amphetamine withdrawal.
    • Patients with regressive symptoms worsened, while those with florid, non-regressive symptoms improved.
    • Lower baseline skin conductance and habituation were observed in positive responders.
    • Attention test performance improved in positive responders after amphetamine administration.

    Conclusions:

    • Amphetamine augmentation can enhance work capacity in select chronic schizophrenic patients.
    • Response to amphetamine is linked to specific symptom profiles, particularly florid non-regressive symptoms.
    • Findings suggest variations in dopaminergic sensitivity among schizophrenic patients.
    • Autonomic and attentional measures may differentiate responders, indicating potential biomarkers.