Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

715
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
715
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

503
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
503
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Schizophrenia01:17

Schizophrenia

1.3K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.3K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

642
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
642
Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

467
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
467

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.

Schizophrenia bulletin open·2026
Same author

Return on investment of enhanced primary youth mental health services in a large Canadian urban centre: a retrospective cohort study.

The lancet. Psychiatry·2026
Same author

Interventions to support recovery of people with psychosis in low-income and middle-income countries: a systematic review.

The lancet. Psychiatry·2026
Same author

Knowing How to Ask About Digital Culture in Youth Mental Health Care: A Co-Designed Tool.

Early intervention in psychiatry·2026
Same author

Fostering Accessibility to Mental Health Services for Youth Experiencing Homelessness in Montreal, Canada: A Historical Cohort Comparison Study.

The International journal of social psychiatry·2026
Same author

The Clinical Staging Model in Psychosis: a Cross-Disciplinary Critical Appraisal Informed by Oncology.

Schizophrenia bulletin·2026

Related Experiment Video

Updated: Feb 28, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K

Is the Clinical High-Risk State a Valid Concept? Retrospective Examination in a First-Episode Psychosis Sample.

Jai L Shah1, Anne Crawford1, Sally S Mustafa1

  • 1The authors are with the Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, and the Department of Psychiatry, McGill University, Montréal.

Psychiatric Services (Washington, D.C.)
|June 16, 2017
PubMed
Summary

Most first episode psychosis patients experienced clinical high-risk symptoms before their first episode. This supports early intervention for psychosis prevention and treatment.

Keywords:
Clinical High-RiskEarly interventionFirst EpisodePsychopathologyPsychosesTransition

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.9K

Related Experiment Videos

Last Updated: Feb 28, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.9K

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • The clinical high-risk (CHR) state for psychosis is a potential target for early intervention.
  • The effectiveness of CHR-focused initiatives depends on whether most first episode psychosis (FEP) patients experience CHR symptoms beforehand.

Purpose of the Study:

  • To determine the proportion of FEP patients who experienced CHR symptoms prior to psychosis onset.
  • To characterize these pre-psychotic symptoms.

Main Methods:

  • Semistructured interviews with 351 FEP patients and families, supplemented by chart reviews.
  • Expert consensus (N=30) identified 27 early signs/symptoms as attenuated positive or subthreshold psychotic symptoms (APSPS).

Main Results:

  • Nine signs/symptoms were identified as APSPS by experts.
  • Over half of FEP patients (68% of completers) experienced at least one APSPS before their FEP.
  • Patients with and without APSPS showed similar social, demographic, and clinical characteristics.

Conclusions:

  • A majority of FEP patients exhibit prior APSPS, validating the CHR construct for early identification.
  • This supports the viability of CHR-based interventions for psychosis prevention and treatment.
  • A notable minority of FEP patients do not report prior APSPS, indicating a need for broader identification strategies.