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Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans
Kavita Ragini1, Andrew M Piggott2, Peter Karuso3
1Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney NSW 2109, Australia. kavita.ragini@students.mq.edu.au.
Abstract:
Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.
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