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Updated: Feb 28, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
Published on: January 27, 2023
Osteoblast Role in Rheumatic Diseases
Addolorata Corrado1, Nicola Maruotti2, Francesco Paolo Cantatore3
1Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, 71122 Foggia, Italy. ada.corrado@unifg.it.
Abstract:
Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphogenetic proteins (BMPs) pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases.
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