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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Osteoblast Role in Rheumatic Diseases.

Addolorata Corrado1, Nicola Maruotti2, Francesco Paolo Cantatore3

  • 1Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, 71122 Foggia, Italy. ada.corrado@unifg.it.

International Journal of Molecular Sciences
|June 16, 2017
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Summary

Osteoblast dysregulation contributes to rheumatic diseases like rheumatoid arthritis and osteoporosis. This review explores abnormal signaling pathways in osteoblasts involved in these conditions.

Keywords:
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Area of Science:

  • Rheumatology
  • Cell Biology
  • Bone Biology

Background:

  • Osteoblast dysfunction is implicated in the pathogenesis of rheumatic diseases.
  • Rheumatic conditions including rheumatoid arthritis, osteoarthritis, and osteoporosis involve abnormal osteoblast activity.

Purpose of the Study:

  • To review current knowledge on osteoblast dysregulation in rheumatic diseases.
  • To highlight the role of altered signaling pathways in osteoblasts within these conditions.

Main Methods:

  • Literature review of current research on osteoblast function in rheumatic diseases.
  • Analysis of signaling pathways such as Wnt, RANKL/OPG, and BMPs in osteoblasts.

Main Results:

  • Osteoblast growth, differentiation, and activity are altered in various rheumatic diseases.
  • Abnormalities in Wnt, RANKL/OPG, and BMP signaling pathways are observed in osteoblasts.

Conclusions:

  • Osteoblast dysregulation is a key factor in the development of rheumatic diseases.
  • Understanding these molecular mechanisms is crucial for therapeutic strategies.