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Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging
Published on: March 2, 2015
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Photoacoustic Drug Delivery
Yuqi Zhang1,2, Jicheng Yu3,4, Anna R Kahkoska5
1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. yzhang96@ncsu.edu.
Sensors (Basel, Switzerland)
|June 16, 2017
Summary
Photoacoustic imaging (PAI) offers advanced non-invasive bioimaging with deeper penetration and higher resolution. This review explores PAI-guided drug delivery systems and their theranostic potential.
Area of Science:
- Biomedical Imaging
- Nanotechnology
- Drug Delivery Systems
Background:
- Photoacoustic (PA) technology provides non-invasive bioimaging with superior resolution and depth compared to conventional optical methods.
- PA imaging (PAI) is evolving beyond diagnostics into theranostic applications, including targeted drug delivery.
- PAI offers precise spatial and temporal control for therapeutic interventions.
Purpose of the Study:
- To review recent advancements in photoacoustic imaging-mediated drug delivery systems.
- To provide an overview of various PAI agents designed for drug delivery applications.
- To discuss current challenges and future opportunities in PA therapy and drug delivery.
Main Methods:
- Literature review of recent research on PAI-mediated drug delivery.
- Analysis of different PAI agent designs for drug delivery.
- Discussion of theranostic applications and challenges in PA therapy.
Main Results:
- PAI enables higher resolution and deeper imaging than conventional optical methods.
- PAI-guided drug delivery allows for remotely controlled and targeted therapeutic interventions.
- Various PAI agents have been developed for enhanced drug delivery efficacy.
Conclusions:
- PAI-mediated drug delivery represents a promising theranostic approach with significant clinical translation potential.
- Further research into PAI agents and therapeutic strategies is needed to overcome current challenges.
- PAI technology is poised to revolutionize non-invasive diagnostics and targeted therapies.
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