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Related Experiment Video

Updated: Feb 28, 2026

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion
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[Postoperative cerebral dysfunction].

N V Tsygan1, M M Odinak1, G G Khubulava1

  • 1Kirov Military Medical Academy, Saint Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 16, 2017
PubMed
Summary

Postoperative brain dysfunction affects 44.2% of patients undergoing coronary artery bypass surgery. Preoperative cytoflavin treatment can reduce delayed cognitive impairment, improving patient outcomes.

Keywords:
cytoflavindeferred cognitive impairmentneuroprotectionperioperative strokepostoperative cerebral dysfunctionsymptomatic delirium of the early postoperative period

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Area of Science:

  • Cardiovascular Surgery
  • Neuroscience
  • Pharmacology

Background:

  • Postoperative brain dysfunction (PBD) is a significant complication following cardiac surgery.
  • Understanding its structure, risk factors, and prevention is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the structure, risk factors, and prevention strategies for PBD in patients undergoing coronary artery bypass surgery (CABG) with cardiopulmonary bypass (CPB).

Main Methods:

  • A study involving 77 patients undergoing elective CABG, comparing on-pump (CPB) and off-pump techniques.
  • A subgroup of 24 CPB patients received preoperative cerebroprotective treatment with cytoflavin.
  • Dynamic neurological, neuropsychological, and instrumental examinations were performed pre- and postoperatively.

Main Results:

  • PBD was diagnosed in 44.2% of patients, with delayed cognitive impairment being the most frequent type (36.4%).
  • Risk factors for PBD after CABG with CPB were identified.
  • Preoperative cytoflavin administration reduced the severity of delayed cognitive impairment and demonstrated a favorable safety profile.

Conclusions:

  • PBD is a distinct nosological entity with diverse etiological factors and pathogenetic mechanisms.
  • Effective prevention and management strategies are essential for optimizing surgical treatment outcomes.
  • Cerebroprotective agents like cytoflavin show promise in mitigating cognitive decline after CABG.