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Evaluation of polyneuropathy and associated risk factors in children with type 1 diabetes mellitus

Hande Türkyilmaz1, Orkide Güzel1, Selvinaz Edizer1

  • 1Department of Pediatric Neurology, Dr. Behçet Uz Children's Training and Research Hospital, İzmir, Turkey.

Turkish Journal of Medical Sciences
|June 17, 2017
PubMed

Insights

Diabetic neuropathy (DN) affects 22.5% of pediatric diabetes mellitus (DM) patients, with duration and ketoacidosis as key risk factors. Poor metabolic control in early DM stages significantly increases neuropathy risk in children.

Area of Science:

  • Pediatric Endocrinology
  • Neurology
  • Metabolic Diseases

Background:

  • Diabetes mellitus (DM) is a prevalent global metabolic disease.
  • Diabetic neuropathy (DN) is a chronic complication of DM, rarely reported in children due to its long latency.
  • Identifying DN incidence and risk factors in pediatric DM is crucial.

Purpose of the Study:

  • To determine the incidence rate of diabetic neuropathy (DN) in pediatric patients with diabetes mellitus (DM).
  • To assess the risk factors associated with the development of DN in this population.

Main Methods:

  • Retrospective review of data from 111 pediatric DM patients (January 2011 - May 2014).
  • Nerve conduction studies (NCS) utilized as the gold standard for DN diagnosis.
  • Linear regression analysis applied to identify correlations with DN presence.

Main Results:

  • Symptomatic DN incidence was 13.5%; EMG-diagnosed DN incidence was 22.5%.
  • Positive correlations identified between diabetes duration, diabetic ketoacidosis history, and DN.
  • Poor metabolic control, particularly early in the disease, emerged as a significant risk factor.

Conclusions:

  • Poor metabolic control in early pediatric DM is a primary risk factor for neuropathy.
  • Long-term prospective studies evaluating nerve conduction in children with DM are recommended.
  • This research highlights the importance of early intervention and management in preventing pediatric DN.
Abstract

Keywords:
Diabetic neuropathychildrendiabetic ketoacidosisnerve conduction studies

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