Related Experiment Video
Updated: Dec 22, 2025
11:56
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
10.3K
Evolution of circadian rhythms: from bacteria to human
Utpal Bhadra1, Nirav Thakkar1, Paromita Das2
1Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Hyderabad, 500007, India.
Sleep Medicine
|June 17, 2017
Summary
Biological clocks maintain bodily rhythms but can be disrupted by travel across time zones. Evolution has equipped organisms with mechanisms to reset these internal clocks to adapt to new environmental cues.
Area of Science:
- Chronobiology
- Evolutionary Biology
- Physiology
Background:
- The human body operates on internal biological clocks synchronized to a 24-hour cycle, influenced by solar movements.
- Rapid travel across time zones disrupts external cues, leading to desynchronization of physiological activities like sleep-wake patterns and eating habits.
Purpose of the Study:
- To review the evolutionary pathways and molecular mechanisms underlying the adaptation of circadian rhythms.
- To understand how organisms reset their biological clocks when exposed to changing environmental cues across different time zones.
Main Methods:
- Literature review of studies on circadian rhythms and their evolutionary adaptation.
- Analysis of molecular mechanisms and research tools used to investigate biological clock resetting.
Main Results:
- Circadian clock resetting mechanisms have evolved across diverse species, from bacteria to humans.
- These evolutionary adaptations are crucial for organisms to synchronize their internal clocks with external cues in different geographical zones.
Conclusions:
- The evolution of circadian mechanisms plays a vital role in enabling organisms to adapt to varying environmental conditions.
- Understanding these adaptive strategies provides insights into maintaining physiological homeostasis across different time zones.
Keywords:
BacteriaFeedback loopHuman evolutionary divergenceTranscriptional and post-transcriptional regulationMore Related Videos
06:53Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
8.7K
10:38Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
23.0K
Related Concept Videos
02:45Biological Clocks and Seasonal Responses
41.3K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.3K
01:21Three-Domain System of Life
644
Ribosomal RNA (rRNA) sequence analysis revealed three distinct groups of cells: eukaryotes, bacteria, and archaea. In 1978, Carl R. Woese proposed the concept of domains, a taxonomic level above kingdoms, to differentiate these groups. He suggested that archaea and bacteria, despite their similar appearance, represent separate domains. Domains differ in rRNA, membrane lipid structure, transfer RNA, and antibiotic sensitivity.In this classification, animals, plants, and fungi belong to the...
644
02:19Circadian Rhythms and Gene Regulation
4.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.4K
01:24Eukaryotic Evolution
39.9K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
39.9K
02:31Synteny and Evolution
3.7K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.7K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
282
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
282