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Using endogenous saccades to characterize fatigue in multiple sclerosis.

Marisa Ferreira1, Paulo A Pereira2, Marta Parreira3

  • 1Vision Rehabilitation Lab.; Centre/Department of Physics and Optometry, University of Minho, Braga, Portugal; Association "Todos com a Esclerose Multipla (TEM)", Braga, Portugal.

Multiple Sclerosis and Related Disorders
|June 17, 2017
PubMed
Summary

Eye movement analysis, specifically saccades, can detect fatigue in Multiple Sclerosis (MS) patients. This research shows altered saccade metrics in MS patients experiencing fatigue, offering a new diagnostic approach.

Keywords:
FatigueFunctional assessmentMultiple SclerosisSaccades

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Clinical Neurology

Background:

  • Multiple Sclerosis (MS) is associated with neural circuit dysfunction, potentially leading to fatigue.
  • Fatigue in MS is often subjective and difficult to quantify using standard methods.
  • Investigating objective biomarkers for MS-related fatigue is crucial for patient management.

Purpose of the Study:

  • To determine if saccadic eye movements can serve as an objective indicator of fatigue in Multiple Sclerosis patients.
  • To explore the relationship between fatigue severity and saccade parameters in MS.

Main Methods:

  • Recruited MS patients (EDSS<=3) and age-matched controls.
  • Monitored eye movements using an infrared eyetracker during a saccade paradigm.
  • Assessed fatigue using the Fatigue Severity Scale (FSS) to categorize MS patients into fatigue and non-fatigue subgroups.

Main Results:

  • Significant differences in saccade latency, peak velocity, and amplitude were observed between MS fatigue, MS non-fatigue, and control groups.
  • Saccade latency differed significantly between MS fatigue and non-fatigue groups (16.9ms) and MS fatigue and controls (15.5ms).
  • FSS scores correlated with saccade peak velocity and amplitude, indicating a link between fatigue severity and eye movement alterations.

Conclusions:

  • Saccade testing reveals objective changes in eye movements associated with fatigue in MS patients.
  • Eye movement analysis offers a complementary, objective measure for fatigue assessment in MS, overcoming limitations of subjective inventories.
  • Findings support the use of saccade metrics in understanding MS-induced functional changes and may aid clinical trials and treatment decisions.