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Tocosome: Novel drug delivery system containing phospholipids and tocopheryl phosphates
M R Mozafari1, R Javanmard1, M Raji1
1Australasian Nanoscience and Nanotechnology Initiative, Clayton, 3168 Victoria, Australia.
International Journal of Pharmaceutics
|June 17, 2017
Summary
Vitamin E derivatives, alpha-tocopheryl phosphate (TP) and di-alpha-tocopheryl phosphate (T2P), show promise as safe nanocarriers for drug delivery. These novel tocosomes offer stable, efficient encapsulation of therapeutics without harsh chemicals.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Vitamin E derivatives, alpha-tocopheryl phosphate (TP) and di-alpha-tocopheryl phosphate (T2P), are being explored for therapeutic applications.
- Developing safe and effective nanocarrier systems is crucial for drug protection and delivery.
Purpose of the Study:
- To investigate the potential of TP and T2P as components of novel nanocarrier systems.
- To evaluate the characteristics and stability of these nanocarriers for therapeutic delivery.
Main Methods:
- Novel nanocarriers (tocosomes) were prepared using the Mozafari method, incorporating TP, T2P, and various lipids/phospholipids.
- The preparation avoided toxic solvents, detergents, sonication, or high-shear homogenization.
- 5-fluorouracil was used as a model drug for encapsulation studies.
Main Results:
- The prepared tocosomes exhibited narrow size distribution.
- Acceptable encapsulation efficiency for the model drug was achieved.
- The nanocarrier systems demonstrated long-term stability, exceeding two years.
Conclusions:
- TP and T2P are suitable for developing safe and stable nanocarrier systems.
- The Mozafari method provides a gentle and effective approach for tosome preparation.
- These vitamin E-based nanocarriers show significant potential for drug protection and delivery applications.
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