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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Updated: Feb 28, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
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Ineffective cough and mechanical mucociliary clearance techniques.

A Fernández-Carmona1, L Olivencia-Peña1, M E Yuste-Ossorio1

  • 1Servicio de Medicina Intensiva, Complejo Hospitalario Universitario de Granada, Granada, España.

Medicina Intensiva
|June 17, 2017
PubMed
Summary

Ineffective cough, a serious condition, can be managed with mechanical cough assist devices and intrapulmonary percussive ventilation. These systems aid patients unable to clear their airways effectively, particularly in intensive care settings.

Keywords:
Aclaramiento mucociliarCough assistIntrapulmonary percussive ventilationMucociliary clearanceTos asistidaTos mecánicaVentilación percutora intrapulmonar

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Area of Science:

  • Respiratory Physiology
  • Critical Care Medicine
  • Pulmonary Rehabilitation

Background:

  • Cough is a vital airway defense mechanism.
  • Ineffective cough, due to muscle weakness or impaired mucociliary function, can lead to life-threatening situations.
  • Mechanical interventions are necessary when patients cannot cough effectively.

Purpose of the Study:

  • To review clinical practice recommendations for mechanical cough assist (MCA) systems.
  • To examine the indications and usage of intrapulmonary percussive ventilation (IPV) systems.
  • To provide guidance on managing ineffective cough in clinical settings.

Main Methods:

  • Literature review of current clinical practice recommendations.
  • Analysis of studies on mechanical cough assist devices.
  • Evaluation of research on intrapulmonary percussive ventilation.

Main Results:

  • Mechanical systems are increasingly utilized in Intensive Care Units (ICUs) for ineffective cough.
  • MCA and IPV offer viable solutions for patients with impaired cough function.
  • Evidence supports the use of these devices in specific clinical scenarios.

Conclusions:

  • Mechanical cough assist and intrapulmonary percussive ventilation are essential tools for managing ineffective cough.
  • Adherence to clinical guidelines ensures optimal patient outcomes.
  • Further research may refine indications and techniques for these interventions.