Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Cancer02:18

Cancer

55.1K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
55.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Brain Network Connectivity Predicts Survival in Diffuse Midline Glioma.

Cancer discoveryยท2026
Same journal

First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts.

Cancer discoveryยท2026
Same journal

CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-driven Alveolar Rhabdomyosarcoma.

Cancer discoveryยท2026
Same journal

CDK8 inhibition induces Mediator trapping and impairment of the EWSR1::FLI1 transcriptional program in Ewing sarcoma.

Cancer discoveryยท2026
Same journal

SEZ6-Targeted ADC Shows Preliminary Efficacy in Small Cell Lung Cancer.

Cancer discoveryยท2026
Same journal

Nonprofit Acquires Abandoned Leukemia Drug Supply.

Cancer discoveryยท2026

Related Experiment Video

Updated: Feb 28, 2026

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
13:34

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

Published on: April 6, 2016

10.7K

Modeling Cancer Mutations in 3-D

    Cancer Discovery
    |June 17, 2017
    PubMed
    Summary

    Scientists can now explore cancer mutations and their effects on human proteins using COSMIC-3D. This free web tool aids in understanding protein structure and function to develop new cancer drugs.

    Area of Science:

    • Genomics
    • Structural Biology
    • Pharmacology

    Background:

    • Cancer mutations alter protein structure and function, impacting disease progression.
    • Understanding these changes is crucial for targeted cancer therapy development.

    Purpose of the Study:

    • To introduce COSMIC-3D, a novel tool for visualizing cancer mutation impacts on protein structure.
    • To provide a freely accessible resource for researchers investigating cancer genomics and protein function.

    Main Methods:

    • Development of COSMIC-3D, integrating mutation data with protein structural information.
    • Web-based platform enabling interactive exploration of over 8,000 human proteins and associated cancer mutations.

    Main Results:

    More Related Videos

    Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
    05:54

    Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

    Published on: September 5, 2018

    9.1K
    Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model
    08:08

    Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model

    Published on: June 11, 2014

    16.4K

    Related Experiment Videos

    Last Updated: Feb 28, 2026

    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
    13:34

    A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

    Published on: April 6, 2016

    10.7K
    Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
    05:54

    Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

    Published on: September 5, 2018

    9.1K
    Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model
    08:08

    Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model

    Published on: June 11, 2014

    16.4K
  • COSMIC-3D offers a comprehensive view of how specific mutations affect protein conformation and activity.
  • The tool visualizes mutation data across a large proteome, facilitating hypothesis generation.

    • Conclusions:

    • COSMIC-3D is a valuable resource for cancer researchers, enhancing the understanding of mutation-driven protein alterations.
    • This tool is expected to accelerate the design and development of novel anti-cancer therapeutics.