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Long noncoding RNAs: lincs between human health and disease
Zhi Hao Kwok1, Yvonne Tay2,3
1Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, Singapore 117599.
Biochemical Society Transactions
|June 17, 2017
Summary
Long noncoding RNAs (lncRNAs) are key regulators in cellular processes and human diseases. This review highlights their functions, mechanisms, and potential as diagnostic and therapeutic targets in cancer.
Area of Science:
- Molecular Biology
- Genomics
- Cancer Research
Background:
- Long noncoding RNAs (lncRNAs) are a vast and diverse class of transcripts.
- High-throughput sequencing has accelerated lncRNA discovery and functional identification.
- lncRNA dysregulation is implicated in numerous human diseases, particularly cancer.
Purpose of the Study:
- To summarize current knowledge on lncRNA functions and mechanisms.
- To focus on the role of lncRNAs in cancer biology.
- To discuss the clinical potential of lncRNAs as biomarkers and therapeutic targets.
Main Methods:
- Literature review and synthesis of existing research on lncRNAs.
- Focus on studies investigating lncRNA roles in cellular processes and disease.
- Analysis of data pertaining to lncRNA dysregulation in cancer.
Main Results:
- lncRNAs play critical regulatory roles in diverse cellular functions.
- Specific lncRNAs are demonstrably involved in the development and progression of cancer.
- Evidence supports the utility of lncRNAs in cancer diagnostics and therapeutics.
Conclusions:
- lncRNAs are crucial molecular players in biological systems and disease.
- Understanding lncRNA mechanisms offers insights into cancer pathogenesis.
- lncRNAs hold significant promise for clinical applications in oncology.
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