Harnessing the immune response to target tumors

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Updated: Feb 28, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.3K

Luisa Manning1, John Nemunaitis1,2

  • 1Gradalis, Inc., Dallas, TX, USA.

F1000Research
|June 17, 2017
PubMed

Insights

Targeted immune therapies in oncology are emerging, with specific targets identified for anticancer response. This review explores these targets and their link to clinical effectiveness in cancer treatment.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Immune-based targeted therapy in oncology is a developing field.
  • Understanding immune function in anticancer responses is advancing.
  • Specific targets linked to sensitivity and resistance in targeted immune therapy are being identified.

Purpose of the Study:

  • To review the relationship between targeted immune therapeutics and clinical responsiveness.
  • To summarize identified targets associated with sensitivity and resistance to immune therapy.

Main Methods:

  • Literature review of targeted immune therapeutics.
  • Analysis of clinical responsiveness data.
  • Identification of key signaling pathways.

Main Results:

  • Several targeted immune therapeutics show potential in oncology.
  • Specific molecular targets correlate with patient response.
  • Understanding resistance mechanisms is crucial for efficacy.

Conclusions:

  • Targeted immune therapy holds promise for cancer treatment.
  • Further research into specific targets can optimize therapeutic strategies.
  • Clinical responsiveness is associated with identified immune targets.
Keywords:
CAR-T cell therapyadoptive T-cell therapyanticancer responsecheckpoint inhibitorstargeted immune therapy

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