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Lugol's solution-induced painless thyroiditis.

Ji Wei Yang1, Jacques How1

  • 1Division of Endocrinology and Metabolism, Department of Medicine, McGill University Health Centre, Montreal, QuebecCanada.

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This summary is machine-generated.

Lugol's solution, typically used short-term for thyroid conditions, can rarely induce painless thyroiditis with prolonged off-label use. This case highlights the potential harm of excess iodine in susceptible individuals.

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Area of Science:

  • Endocrinology
  • Internal Medicine
  • Pharmacology

Background:

  • Lugol's solution is a common treatment for Graves' disease and thyrotoxicosis.
  • Prolonged or off-label use of Lugol's solution is not standard practice.
  • Iodine excess is known to cause both hyperthyroidism and hypothyroidism.

Purpose of the Study:

  • To report a rare case of painless thyroiditis induced by Lugol's solution.
  • To highlight the potential adverse effects of prolonged iodine intake.
  • To emphasize the importance of judicious use of Lugol's solution.

Main Methods:

  • A case study of a 59-year-old woman prescribed Lugol's solution for menopausal symptoms.
  • Clinical presentation, laboratory tests (TSH, free T4, T3), and treatment response were monitored.
  • Review of existing literature on Lugol's solution and iodine-induced thyroid dysfunction.

Main Results:

  • The patient developed symptoms of thyrotoxicosis (low TSH, elevated free T4) after prolonged Lugol's solution use.
  • Subsequent treatment with methimazole led to hypothyroidism.
  • Discontinuation of methimazole resulted in spontaneous euthyroidism.

Conclusions:

  • Lugol's solution can rarely induce painless thyroiditis, particularly with off-label and prolonged use.
  • Individuals with underlying thyroid conditions may be more susceptible to iodine-induced thyroid dysfunction.
  • Careful consideration of iodine intake is crucial to prevent adverse thyroid events.