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Updated: Feb 28, 2026
Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice
Zenghua Lin1,2, Sachiko Kajigaya1, Xingmin Feng1
1Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD USA.
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We analyzed hematopoietic phenotypes in Peromyscus leucopus (PL) mice at young (2-9 months), middle (22-23 months) and old (33-46 months) ages aimed at characterizing age-associated changes in this unique rodent species. We found a significantly higher number of monocytes in old PL mice in peripheral blood, and higher proportions of CD44+ cells in blood, spleen and bone marrow in old PL mice than in middle and young counterparts. We conclude that elevated blood monocyte counts and up-regulated hematopoietic cell CD44 expression are two useful aging biomarkers for PL mice.
