Related Experiment Video
Updated: Dec 22, 2025

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
The Role of Mast Cells in Intracerebral Hemorrhage
Mustafa Yehya1, Michel T Torbey2,3
1Cerebrovascular and Neurocritical Care Division, Department of Neurology, Wexner Medical Center, The Ohio State University, 333 W. 10th Ave, Graves Hall, Rm. 3172, Columbus, OH, 43210, USA.
Abstract:
Mast cells are first responders to intracerebral hemorrhage. They release potent mediators that can disrupt the blood-brain barrier promoting injury, vasogenic edema formation, and hematoma exacerbation. Also, mast cells recruit other inflammatory cells that maintain and amplify brain damage. Given their early role in the cascade of events in intracerebral hemorrhage, mast cells may offer an alternative target for antichemotactic interventions.
More Related Videos
Related Concept Videos
Inflammation
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...

