Palladium-catalyzed acid-free Fujiwara-Moritani alkenylation of 4-thiazolidinones
Anuj Patel1, Janki Patel1, Kishor H Chikhalia2
1Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, 380009, India.
Abstract:
Herein, we report a facile method for the alkenylation of a 4-thiazolidinone motif without using external acid and high-pressure gas, which are required in conventional Fujiwara-Moritani reactions. Mild reaction conditions, one-pot synthesis, and utilization of an oxidant made this process more feasible in comparison with previously reported methods. Functionalization of the slightly more acidic [Formula: see text] C-H bond with the less acidic [Formula: see text] C-H bond yielded the alkenylated motif. This pathway opens new possibilities for organic synthesis.
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