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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
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DNA methylation patterns in ulcerative colitis-associated cancer: a systematic review
Ruth A Emmett1, Katherine L Davidson1, Nicholas J Gould1
1Warwick Medical School, University of Warwick, Coventry, UK.
Epigenomics
|June 17, 2017
Summary
DNA methylation patterns in ulcerative colitis-associated cancer (UCC) differ from sporadic colorectal cancer (SCRC). Seven genes show promise as biomarkers for identifying disease risk.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory disease.
- Ulcerative colitis-associated cancer (UCC) is a severe complication of UC.
- Understanding UCC etiology is crucial for developing biomarkers and therapeutic targets.
Purpose of the Study:
- To investigate DNA methylation patterns in UCC.
- To compare methylation profiles between UCC and sporadic colorectal cancer (SCRC).
- To identify potential biomarkers for UCC risk.
Main Methods:
- Systematic literature search using PRISMA protocol across three databases.
- Comparative analysis of DNA methylation in UCC versus SCRC.
- Identification of differentially methylated genes in UCC.
Main Results:
- Similarities and differences in DNA methylation patterns between UCC and SCRC were observed.
- Generally lower promoter hypermethylation in UCC compared to SCRC.
- Specific genes (RUNX3, MINT1, MYOD, p16 exon1, EYA4, ESR) showed high methylation in UCC.
Conclusions:
- DNA methylation patterns distinguish UCC from SCRC.
- Seven genes are identified as potential biomarkers for UCC risk assessment.
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