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Telomere Length and Bipolar Disorder.

Timothy R Powell1,2, Danai Dima3,4,5, Sophia Frangou5

  • 1Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|June 17, 2017
PubMed
Summary
This summary is machine-generated.

Shortened telomere length is linked to familial risk for bipolar disorder (BD). This finding suggests telomeres may indicate susceptibility and highlights potential neuroprotective effects of lithium treatment.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Telomere length variation is heritable and a potential biomarker for neuropsychiatric disorders.
  • Telomere length is associated with memory function and hippocampal morphology.

Purpose of the Study:

  • Investigate telomere length in relation to familial risk and disease expression in bipolar disorder (BD).
  • Assess the association between telomere length, hippocampal volume, and episodic memory in BD patients, relatives, and healthy controls.

Main Methods:

  • Quantitative PCR and a telomere-to-single-copy-gene ratio method to measure telomere length in genomic DNA from buccal smears.
  • Magnetic resonance imaging (MRI) for hippocampal volume measurement.
  • Verbal paired associates test for episodic memory assessment.

Main Results:

  • Telomere length was significantly shorter in psychiatrically well relatives compared to healthy controls (p=0.007).
  • Relatives (regardless of psychiatric status) and BD patients not on lithium had shorter telomeres than lithium-treated BD patients.
  • Shorter telomere length correlated positively with hippocampal volume and delayed recall in the entire sample.

Conclusions:

  • Shortened telomere length is associated with familial risk for bipolar disorder.
  • Lithium treatment may possess neuroprotective properties, warranting further investigation.