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Related Experiment Video

Updated: Feb 28, 2026

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
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Reduced Mastication Impairs Memory Function.

Y Fukushima-Nakayama1,2, Takehito Ono1, M Hayashi1

  • 11 Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.

Journal of Dental Research
|June 17, 2017
PubMed
Summary
This summary is machine-generated.

Chewing during development is crucial for cognitive function. Reduced mastication in juvenile mice impaired spatial memory and learning by affecting the hippocampus and brain-derived neurotrophic factor (BDNF).

Keywords:
growth and developmentmemory disordersneurogenesisneurotrophic factorsoral healthsynapses

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Oral Health

Background:

  • Mastication is vital for overall health, but dysfunction, common in the elderly, can impair cognition.
  • Masticatory stimulation influences central nervous system development and maxillofacial growth.
  • The link between mastication and cognitive function during development needs further mechanistic exploration.

Purpose of the Study:

  • To investigate the impact of reduced masticatory stimulation during the growth period on cognitive function.
  • To elucidate the cellular and molecular mechanisms underlying the relationship between mastication and cognitive function in early life.

Main Methods:

  • Utilized an in vivo model with juvenile mice fed a powder diet to simulate reduced masticatory stimuli.
  • Assessed spatial memory and learning functions.
  • Analyzed hippocampal morphology, neuronal activity, neurogenesis, and brain-derived neurotrophic factor (BDNF) expression.

Main Results:

  • Reduced mastication led to impaired spatial memory and learning in juvenile mice.
  • Observed morphological changes and decreased activity in the hippocampus.
  • Found decreased neurogenesis, neuronal activity, and BDNF expression in the hippocampus.

Conclusions:

  • Masticatory stimulation during the growth period is essential for promoting cognitive function, particularly spatial memory.
  • A functional linkage exists between mastication and brain development, mediated by hippocampal changes.
  • Findings suggest potential therapeutic targets for masticatory function-related cognitive dysfunction.