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Published on: June 21, 2018
Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis
Shujuan Yang1, Chaoying Li1, Xuejiao Li2
1Department of Health Related Social & Behavioral Science, West China School of Public Health, Sichuan University, Chengdu, China.
Aim:
We performed a meta-analysis to determine a more precise relationship of IL-17A and IL-17F polymorphisms with cervical cancer risk.
Materials & Methods:
PubMed, CNKI and Wan Fang databases were searched for studies on these associations using STATA version 10.0 software.
Results:
Five studies were included. The AG and AA genotypes and A allele of IL-17A rs2275913 were correlated with an elevated risk of cervical cancer. The TT genotype and T allele of IL-17A rs3748067 and the CC genotype and C allele of IL-17F rs763780 carried a moderate risk of cervical cancer, when compared with the wild-type genotype.
Conclusion:
IL-17A and IL-17F polymorphisms therefore have the potential to act as predictive biomarkers for cervical cancer risk.
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