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Published on: September 14, 2021
Effects of Notch signalling pathway on the relationship between vascular endothelial dysfunction and endothelial
1a Department of Pediatric Surgery Union Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
Insights
The Notch signaling pathway promotes atherosclerosis (AS) by worsening vascular endothelial dysfunction and stromal transformation. Targeting this pathway offers a potential strategy for treating AS and related cardiovascular diseases.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Pathology
Background:
- Cardiovascular and cerebrovascular diseases are a leading cause of death, with increasing incidence due to aging populations and improved living standards.
- Atherosclerosis (AS) is a major contributor to these diseases, making it a critical area for clinical and basic research.
- Understanding the molecular mechanisms underlying AS, particularly the role of endothelial dysfunction, is crucial for developing effective treatments.
Purpose of the Study:
- To investigate the role of the Notch signaling pathway in the relationship between endothelial dysfunction and endothelial stromal transformation in atherosclerosis.
- To elucidate how Notch signaling influences the progression of AS.
- To explore the therapeutic potential of modulating the Notch signaling pathway for AS treatment.
Main Methods:
- Establishment of an atherosclerotic model in a research setting.
- Analysis of Notch signaling pathway activation within the atherosclerotic model.
- Evaluation of the impact of Notch signaling on vascular endothelial function.
- Assessment of Notch signaling's influence on endothelial stromal transformation.
Main Results:
- The Notch signaling pathway was found to be activated in the atherosclerotic model.
- Activation of the Notch signaling pathway was shown to enhance AS by promoting vascular endothelial dysfunction.
- The Notch signaling pathway mediates its pro-atherosclerotic effects by promoting endothelial stromal transformation.
- Intervention in the Notch signaling pathway affects endothelial function and stromal transformation, synergistically impacting AS.
Conclusions:
- The Notch signaling pathway plays a significant role in the development and progression of atherosclerosis (AS).
- Modulating the Notch signaling pathway can influence endothelial function and endothelial stromal transformation, offering a potential therapeutic strategy for AS.
- Targeting the Notch signaling pathway presents a promising approach for the treatment of AS and related cardiovascular diseases.
Abstract:
At present, with the improvement of living standards and population aging, the incidence of cardiovascular and cerebrovascular disease is on the rise and has been a serious threat to human health. Statistics show that the current death caused by cardiovascular and cerebrovascular disease has become the first cause of death has been increasing year by year. Therefore, studies on coronary heart disease and atherosclerosis (AS) have become a hot topic in clinical and basic research. In this study, the question of the effect of Notch signalling pathway on the relationship between endothelial dysfunction and endothelial stromal transformation in AS was studied in depth. Based on our results, we drew conclusions as follows. First, the Notch signalling pathway was activated in the atherosclerotic model; secondly, the Notch signalling pathway was demonstrated to enhance AS by promoting vascular endothelial dysfunction; thirdly, it was demonstrated that the Notch signalling pathway was mediated by promoting endothelial and to enhance AS; finally, we confirmed the endothelial function through the Notch signalling pathway to affect the transformation of endothelial stroma to achieve synergistic AS effect. The results of this study have a good guiding significance for the important role of Notch signalling in AS and indicate the ability to influence endothelial function and endothelial stromal transformation by intervening Notch signalling pathway and can affect the relationship between them, and thus eventually achieve the treatment of AS.
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