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Is bisphenol A an environmental obesogen?

Samuel Legeay1, Sébastien Faure1

  • 1MINT, UNIV Angers, INSERM 1066, CNRS 6021, Université Bretagne Loire, IRIS-IBS-CHU, 4 rue Larrey, 49100, Angers, France.

Fundamental & Clinical Pharmacology
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Summary

Bisphenol A (BPA), an endocrine disruptor, is linked to increased obesity risk. Exposure during development and adulthood promotes weight gain and metabolic dysfunction, highlighting BPA as an obesogenic compound.

Keywords:
bisphenol Aendocrine disruptorenvironmental obesogenic compoundsobesity

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Area of Science:

  • Endocrinology
  • Environmental Health
  • Toxicology

Background:

  • Bisphenol A (BPA) is a widely used industrial chemical with endocrine-disrupting properties.
  • Ubiquitous environmental presence leads to continuous human exposure.
  • BPA exposure is controversially linked to adverse health effects, including obesity.

Purpose of the Study:

  • To analyze current evidence on the relationship between Bisphenol A exposure and obesity.
  • To evaluate BPA's role as an obesogenic environmental compound.
  • To identify critical developmental windows for BPA exposure and its impact.

Main Methods:

  • Systematic review and updated analysis of epidemiological, in vivo, and in vitro studies.
  • Examination of BPA's effects on body weight, body mass index, and metabolic parameters.
  • Investigation of BPA's impact on adipogenesis and adipose tissue inflammation.

Main Results:

  • BPA exposure correlates with increased body weight and BMI across all life stages.
  • Prenatal, infancy, and childhood are identified as critical windows of heightened sensitivity.
  • BPA promotes adipogenesis, dysregulates lipids and glucose, and causes adipose tissue inflammation.

Conclusions:

  • Bisphenol A is confirmed as an obesogenic environmental compound.
  • Evidence supports BPA's contribution to obesity pathophysiology through metabolic disruption.
  • Further research is needed to clarify long-term exposure risks and establish precise risk assessments.