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Related Concept Videos

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Generation of a Human iPSC-Based Blood-Brain Barrier Chip
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Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

Lorna Ewart1, Kristin Fabre2, Ananthsrinivas Chakilam3

  • 11 AstraZeneca, Cambridge CB2 0AA, UK.

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Summary

Tissue chips (TCs) offer a paradigm shift in drug discovery by emulating human physiology for more predictive preclinical models. A strategic roadmap and partnership are crucial for their adoption in industrial labs.

Keywords:
Tissue chipsinnovationmicrophysiological systemspartnershippharmacokineticstoxicology

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Area of Science:

  • Biotechnology and Pharmaceutical Sciences
  • Drug Discovery and Development
  • Translational Medicine

Background:

  • Tissue chips (TCs) hold promise for revolutionizing drug discovery by mimicking human physiology.
  • Current preclinical models often lack predictive power, leading to high failure rates in clinical trials.
  • Adoption of TCs in industrial settings faces challenges despite significant scientific innovation.

Purpose of the Study:

  • To outline a strategic roadmap for the adoption of tissue chip technology in industrial drug discovery.
  • To identify key considerations for transforming TC technology from innovators to industrial scientists.
  • To foster a consensus view on accelerating the progression strategy for TC implementation.

Main Methods:

  • Consensus-building among scientists from 13 pharmaceutical companies and National Institutes of Health partners.
  • Analysis of current challenges and requirements for routine industrial adoption of TCs.
  • Development of a strategic roadmap focusing on partnership and contextual understanding.

Main Results:

  • A collaborative approach and understanding of industrial context are essential for successful TC adoption.
  • TCs can enhance the predictive power of preclinical models, moving towards clinically relevant and animal-free drug discovery.
  • Near-term TC applications include filling gaps in disposition, efficacy, and safety assessments.

Conclusions:

  • A partnership between innovators and end-users is vital for the rapid advancement of TC technology.
  • TCs can address real-world challenges in drug discovery and development, accelerating the creation of innovative medicines.
  • This article serves as a resource for the multidisciplinary field of TC development, promoting smooth and rapid implementation.