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Published on: July 24, 2013
Prevalence of non-infectious comorbidities in the HIV-positive population in Belgium: a multicenter, retrospective
Jessie Gunter1, Steven Callens2, Stephane De Wit3
1a Center for Disease Analysis , Lafayette , CO , USA.
Insights
This study characterizes non-infectious comorbidities in aging HIV-positive individuals in Belgium. Key findings include the prevalence of diabetes, hypertension, and chronic kidney disease, highlighting challenges in managing comorbidities to improve patient outcomes.
Area of Science:
- Infectious Diseases
- Public Health
- Gerontology
Background:
- As people with HIV live longer, non-infectious comorbidities (NICMs) significantly impact their quality of life.
- Managing NICMs is crucial for improving long-term outcomes in the aging HIV-positive population.
Purpose of the Study:
- To characterize the prevalence of key NICMs in HIV-positive patients in Belgium.
- To identify factors associated with increased mortality in this population.
Main Methods:
- Retrospective study of 5787 HIV-positive patients.
- Data collected from four AIDS Reference Centers (ARCs) in Belgium.
- Follow-up period: June 2014 to July 2016.
Main Results:
- Prevalence of diabetes mellitus: 5.9%, arterial hypertension: 31%, chronic kidney disease (CKD): 7.8%.
- Cardiovascular events occurred in 2.9% of patients.
- Higher mortality rates observed in patients aged 51-55, with CKD, and with viremic hepatitis C.
Conclusions:
- Addressing NICMs in the aging HIV population is essential to prevent premature morbidity and mortality.
- Standardized data collection across ARCs is needed for better knowledge sharing and countrywide analyses in Belgium.
Objectives:
In Belgium, eleven AIDS Reference Centers (ARCs) and seven AIDS Reference Laboratories diagnose and treat HIV-positive individuals and track patients under care. As AIDS-related deaths are avoided and the HIV-positive population ages, non-infectious comorbidities (NICMs), such as cardiovascular disease, renal disease and certain cancers, play a larger role in the quality and length of patients' lives. This study aims to characterize the HIV-positive population in Belgium in terms of the prevalence of key NICMs.
Methods:
We performed a retrospective study of 5787 HIV-positive patients under follow-up at four ARCs across Belgium between 1st of June 2014 and 1st of July 2016.
Results:
The mean age of patients under follow-up was 46.7 (SD = 11.6) years, and the mean nadir CD4 count was 268.8 cells/mm3 (SD = 189.5). The prevalence of diabetes mellitus, arterial hypertension and chronic kidney disease (CKD) were 5.9, 31 and 7.8%, respectively. Cardiovascular events, defined as the occurrence of myocardial infarction, stroke or an invasive coronary procedure, occurred in 2.9% of patients. The highest age-adjusted mortality rates were observed among patients 51-55 years of age. Mortality rates were also higher among patients with CKD and patients with viremic hepatitis C virus (p < 0.05).
Conclusions:
Helping the aging HIV-positive population avoids premature morbidity and mortality from NICMs represents a key challenge to further improve patient outcomes. Belgium has an advanced system of HIV care and patient management; however, standardized data collection across ARCs is needed to improve knowledge sharing and to support future countrywide analyses.
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