Related Experiment Video
Updated: Feb 28, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Prevalence and risk factors associated with peripheral arterial disease in an adult population from Colombia
Lorena Urbano1, Eliana Portilla2, Wilson Muñoz3
1Department of Physiological Sciences, Faculty of Health Sciences, University of Cauca, Popayán, Colombia; Molecular Diagnostics Unit, InnovaGen Foundation, Popayán, Colombia.
Insights
Peripheral arterial disease (PAD) affects 4.4% of adults in Cauca, Colombia. Hypertension, diabetes, and dyslipidemia are strong predictors, highlighting the need for routine ankle-brachial index screening in high-risk patients.
Area of Science:
- Epidemiology
- Cardiovascular Health
- Public Health
Background:
- Cardiovascular diseases (CVD) are a leading cause of death in Latin America.
- Peripheral arterial disease (PAD) is a significant contributor to atherosclerotic cardiovascular morbidity.
Purpose of the Study:
- To determine the prevalence of PAD in Cauca, Colombia.
- To analyze the distribution of traditional CVD risk factors within this population.
Main Methods:
- A cross-sectional study involving 10,000 participants aged 40 and above.
- Diagnosis of PAD was based on an ankle-brachial index (ABI) of ≤0.9 in either leg.
Main Results:
- The overall prevalence of PAD was 4.4%, with higher rates in females (4.7%) than males (4.0%).
- Diabetes was the most common risk factor (23%). PAD prevalence was notably high in individuals with a history of myocardial infarction (31.0%) or stroke (8.1%).
- Hypertension, diabetes, dyslipidemia, obesity, and smoking were significantly associated with PAD. Combined risk factors, particularly hypertension, diabetes, dyslipidemia, and obesity, dramatically increased PAD risk.
Conclusions:
- Hypertension, diabetes, dyslipidemia, and obesity are identified as strong predictors of PAD.
- Routine ABI measurement is recommended for screening intermediate and high-risk individuals for CVD.
- Early detection and intervention through ABI screening can improve strategies for reducing the burden of CVD.
Background:
Cardiovascular diseases (CVD) are the most important cause of mortality in Latin America, while peripheral arterial disease (PAD) is the third leading cause of atherosclerotic cardiovascular morbidity.
Objective:
To establish the prevalence of PAD and the distribution of traditional CVD risk factors in a population from the Department of Cauca, Colombia.
Methods:
A cross-sectional study was conducted on a total of 10,000 subjects aged ≥40 years, from 36 municipalities. An ankle-brachial index (ABI) ≤ 0.9 in either leg was used as diagnostic criterion of PAD.
Results:
Overall PAD prevalence was 4.4% (4.7% females vs. 4.0% males), with diabetes being the most prevalent risk factor (23%). Among individuals self-reporting a history of acute myocardial infarction or stroke, PAD prevalence was 31.0% and 8.1%, respectively. After adjusting for potential confounders, PAD was significantly associated with hypertension (OR 4.6; 95% CI; 3.42-6.20), diabetes (4.3; 3.17-5.75), dyslipidaemia (3.1; 2.50-3.88), obesity (1.8; 1.37-2.30), and cigarette smoking (1.6; 1.26-1.94). Analysis for the interaction of risk factors showed that diabetes, dyslipidaemia, and obesity accounted for 13.2 times the risk for PAD (6.9-25.4), and when adding hypertension to the model, the risk effect was the highest (17.2; 8.4-35.1).
Conclusions:
Hypertension, diabetes, dyslipidaemia, and obesity, but not smoking were strong predictors of PAD. ABI measurement should be routinely performed as a screening test in intermediate and high-risk patients for CVD prevention. This could lead to an early intervention and follow-up on populations at risk, thus, contributing to improve strategies for reducing CVD burden.
More Related Videos
Related Concept Videos
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease I: Introduction
Peripheral Artery Disease IV: Nursing Management
Peripheral Artery Disease III: Interprofessional Care
Coronary Artery Disease I: Introduction
Peripheral Artery Disease V: Postoperative Nursing Management

