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Cognitive Performance across 3 Frailty Phenotypes: Toledo Study for Healthy Aging
Cristina Rosado-Artalejo1, Jose Antonio Carnicero2, Jose Losa-Reyna1
1Hospital Virgen del Valle, Complejo Hospitalario de Toledo and CIBER of Frailty and Aging (CIBERFES), Toledo, Spain.
Cognitive decline is linked to frailty. Even in prefrail individuals, cognitive impairment may signal early brain changes, suggesting interventions to prevent frailty progression.
Area of Science:
- Gerontology
- Neuroscience
- Public Health
Background:
- Frailty is a significant predictor of adverse health outcomes.
- The relationship between frailty and cognitive function remains insufficiently understood.
Purpose of the Study:
- To evaluate cognitive performance across different stages of frailty.
- To pinpoint the specific frailty stage at which cognitive impairment emerges.
Main Methods:
- Analysis of data from 2044 adults aged 65+ from the Toledo Study for Healthy Aging.
- Assessment of frailty using Frailty Phenotype (FP), Frailty Trait Scale (FTS), and Frailty Index (FI).
- Comprehensive neuropsychological testing across multiple cognitive domains.
Main Results:
- Individuals with severe frailty (frail FP, fourth quartile FTS/FI) exhibited more extensive and pronounced cognitive deficits.
- Cognitive impairment was more prevalent and severe in frail participants compared to prefrail and robust individuals.
Conclusions:
- Cognitive function progressively deteriorates with increasing frailty, irrespective of the assessment tool.
- Cognitive impairment in prefrail individuals may indicate early frailty-related brain changes and warrants intervention.
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