Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypodermis01:02

Hypodermis

8.1K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
8.1K
Loose Connective Tissue01:26

Loose Connective Tissue

10.9K
Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
10.9K
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

27.3K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
27.3K
Functions of Connective Tissues01:17

Functions of Connective Tissues

19.0K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
19.0K
Metabolic States of the Body: The Absorptive State01:25

Metabolic States of the Body: The Absorptive State

1.9K
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
1.9K
Obesity01:24

Obesity

1.4K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

Molecular metabolism·2026
Same author

A deep-learning framework reveals whole-body perturbations at cell level.

Nature·2026
Same author

Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model.

The Journal of clinical investigation·2026
Same author

Impaired glucose tolerance and mild diabetes induce β-cell dysfunction in mice.

Nature communications·2026
Same author

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

Nature communications·2026
Same author

Lipidated interleukin-22 reduces body weight and spares lean mass in mice by a novel gut-acting mechanism additive to GLP-1 agonism.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same journal

Chromosome condensation mechanically primes the nucleus for mitosis.

The EMBO journal·2026
Same journal

NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans.

The EMBO journal·2026
Same journal

Assembly of the catalytic module and the rotor of human ATP synthase.

The EMBO journal·2026
Same journal

Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC.

The EMBO journal·2026
Same journal

Conformational changes of the baseplate regulating tail contraction of Staphylococcus phage 812.

The EMBO journal·2026
Same journal

Cellular assembly and functional resilience of the mammalian RNA exosome.

The EMBO journal·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

45.4K

Adipose tissue: between the extremes.

Alexandros Vegiopoulos1, Maria Rohm2, Stephan Herzig3

  • 1Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.

The EMBO Journal
|June 18, 2017
PubMed
Summary
This summary is machine-generated.

Adipose tissue is vital for energy balance, but its wasting is poorly understood. This review explores the causes and consequences of adipose tissue loss and its impact on metabolic health.

Keywords:
adipose tissue dysfunctioncachexialipodystrophymetabolic disordersobesity

More Related Videos

Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

42.2K
Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
06:50

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

3.2K

Related Experiment Videos

Last Updated: Feb 28, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

45.4K
Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

42.2K
Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
06:50

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

3.2K

Area of Science:

  • Metabolic Physiology
  • Endocrinology
  • Adipose Tissue Biology

Background:

  • Adipose tissue is crucial for energy homeostasis, lipid handling, and endocrine signaling via adipokines and lipokines.
  • Dysfunction in adipose tissue is linked to metabolic disorders like obesity, metabolic syndrome, lipodystrophy, and cachexia.
  • While obesity-related adipose tissue expansion is well-studied, involuntary adipose tissue loss and its mechanisms remain less understood.

Purpose of the Study:

  • To review the current understanding of adipose tissue wasting conditions.
  • To examine the microenvironmental determinants of adipocyte function in pathophysiologies involving adipose tissue loss.

Main Methods:

  • Literature review of studies on adipose tissue wasting.
  • Analysis of microenvironmental factors affecting adipocyte function.
  • Synthesis of current knowledge on metabolic consequences of adipose tissue loss.

Main Results:

  • Adipose tissue wasting is associated with severe metabolic consequences.
  • Microenvironmental factors significantly influence adipocyte function and dysfunction.
  • Specific pathways driving adipose tissue loss are less understood than those driving expansion.

Conclusions:

  • Further research is needed to elucidate the mechanisms of adipose tissue wasting.
  • Understanding adipocyte microenvironments is key to addressing metabolic disorders related to adipose tissue loss.
  • This review highlights critical knowledge gaps in adipose tissue pathophysiology.