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Endothelial dysfunction in rectal cancer patients chronically exposed to ionizing radiation
Tolebay Rakhypbekov1, Ken Inoue2, Laura Pak1
1Semey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Radiation and Environmental Biophysics
|June 18, 2017
Summary
Rectal cancer patients exposed to ionizing radiation show endothelial dysfunction, impacting nitric oxide (NO) production and increasing thrombosis risk. These effects were more pronounced in those living near the nuclear test site.
Area of Science:
- Oncology
- Cardiovascular Medicine
- Environmental Health
Background:
- Chronic exposure to ionizing radiation is a potential risk factor for various health issues.
- Endothelial function plays a crucial role in cardiovascular health and hemostasis.
- Rectal cancer patients may experience unique physiological changes, potentially exacerbated by environmental factors.
Purpose of the Study:
- To investigate endothelial function in rectal cancer patients exposed to chronic ionizing radiation.
- To identify specific markers of endothelial dysfunction and hemostasis disturbances.
- To assess the impact of living in a contaminated area near a nuclear test site on these parameters.
Main Methods:
- Examined 146 individuals, including 76 rectal cancer patients.
- Assessed endothelial function markers such as nitric oxide (NO) production and vasodilatation.
- Measured hemostasis indicators including von Willebrand factor and circulating endotheliocytes.
Main Results:
- Identified complex disturbances in endothelium and hemostasis systems in rectal cancer patients.
- Observed increased nitric oxide (NO) production, decreased vasodilatation, elevated von Willebrand factor, and more circulating endotheliocytes.
- Found stronger correlations between endothelial function and vascular-platelet hemostasis in patients from the contaminated area.
Conclusions:
- Rectal cancer patients exposed to chronic ionizing radiation exhibit significant endothelial dysfunction.
- These dysfunctions correlate with hemostasis alterations, suggesting an increased risk of thrombosis.
- Proximity to the nuclear test site intensifies these vascular-platelet changes, potentially leading to post-treatment complications.
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