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Related Experiment Video

Updated: Feb 28, 2026

Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks
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The brain behaves as a muscle?

Marinella Coco1

  • 1Horus Social Cooperative, Ragusa, Italy. marinella.coco@unict.it.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|June 18, 2017
PubMed
Summary

Lactate accumulation during intense exercise may protect the brain from central fatigue. This finding shifts lactate's role from a fatigue cause to a fatigue protector in the central nervous system.

Area of Science:

  • Exercise Physiology
  • Neuroscience
  • Biochemistry

Background:

  • Lactate accumulates in skeletal muscle during intense anaerobic exercise.
  • Lactate is cleared during aerobic metabolism but can reach the bloodstream.
  • Increased blood lactate during maximal exercise has been observed.

Purpose of the Study:

  • To investigate the role of blood lactate transport to the brain during maximal exercise.
  • To explore lactate's potential function in protecting the central nervous system (CNS) from fatigue.
  • To re-evaluate lactate's role from a fatigue inducer to a fatigue protector.

Main Methods:

  • Observational study during maximal exercise.
  • Analysis of blood lactate levels and transport to the brain.
Keywords:
BrainFatigueLactateMuscle

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  • Assessment of central nervous system function during exercise.

    • Main Results:

    • Blood lactate increases and is transported to the brain during maximal exercise.
    • This transport may preserve the function of primary cortical motor and sensory areas.
    • Lactate's role appears to shift towards protecting CNS structures.

    Conclusions:

    • Lactate may act as a protective agent against central fatigue during maximal exertion.
    • The function of lactate in both muscle and CNS shifts from fatigue causation to fatigue protection.
    • This represents a significant paradigm shift in understanding lactate's physiological role.