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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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Nanoformulations for combination or cascade anticancer therapy

Lei Miao1, Shutao Guo2, C Michael Lin3

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Advanced Drug Delivery Reviews
|June 19, 2017
PubMed

Insights

Nanoparticle drug delivery systems show promise for overcoming cancer treatment resistance by combining therapies. This review explores nanotechnology solutions for co-delivering multiple drugs effectively.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Cancer treatment resistance is a major clinical challenge.
  • Synergistic drug combinations with distinct mechanisms can overcome resistance.
  • Co-delivery of multiple drugs via nanocarriers is complex due to drug property variations.

Purpose of the Study:

  • To review cellular and microenvironment mechanisms of cancer treatment resistance.
  • To discuss nanotechnology-based strategies for effective anti-cancer combination therapy.
  • To highlight advancements in co-loading and cascade delivery systems.

Main Methods:

  • Review of existing literature on nanoparticle drug formulations.
  • Discussion of various nanocarrier types: polymeric nanoparticles, polymer-drug conjugates, lipid nanoparticles.
  • Exploration of lipid-coated drug nanoparticles.

Main Results:

  • Nanoparticle formulations are increasingly FDA-approved for drug delivery.
  • Co-loading and cascade delivery strategies using nanocarriers are being developed.
  • Novel lipid-coated drug nanoparticles offer potential for combination therapy.

Conclusions:

  • Nanotechnology offers promising solutions to overcome cancer treatment resistance.
  • Effective co-delivery of synergistic drug combinations is crucial for advanced cancer therapy.
  • Further development of nanocarrier systems is essential for clinical translation.
Keywords:
CombinationMulti-drug resistanceNanoparticleTumor microenvironment

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