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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Updated: Feb 28, 2026

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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Nanoformulations for combination or cascade anticancer therapy.

Lei Miao1, Shutao Guo2, C Michael Lin3

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Advanced Drug Delivery Reviews
|June 19, 2017
PubMed
Summary
This summary is machine-generated.

Nanoparticle drug delivery systems show promise for overcoming cancer treatment resistance by combining therapies. This review explores nanotechnology solutions for co-delivering multiple drugs effectively.

Keywords:
CombinationMulti-drug resistanceNanoparticleTumor microenvironment

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Cancer treatment resistance is a major clinical challenge.
  • Synergistic drug combinations with distinct mechanisms can overcome resistance.
  • Co-delivery of multiple drugs via nanocarriers is complex due to drug property variations.

Purpose of the Study:

  • To review cellular and microenvironment mechanisms of cancer treatment resistance.
  • To discuss nanotechnology-based strategies for effective anti-cancer combination therapy.
  • To highlight advancements in co-loading and cascade delivery systems.

Main Methods:

  • Review of existing literature on nanoparticle drug formulations.
  • Discussion of various nanocarrier types: polymeric nanoparticles, polymer-drug conjugates, lipid nanoparticles.
  • Exploration of lipid-coated drug nanoparticles.

Main Results:

  • Nanoparticle formulations are increasingly FDA-approved for drug delivery.
  • Co-loading and cascade delivery strategies using nanocarriers are being developed.
  • Novel lipid-coated drug nanoparticles offer potential for combination therapy.

Conclusions:

  • Nanotechnology offers promising solutions to overcome cancer treatment resistance.
  • Effective co-delivery of synergistic drug combinations is crucial for advanced cancer therapy.
  • Further development of nanocarrier systems is essential for clinical translation.