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Related Experiment Videos

Increased free-radical activity in alcoholics.

R Fink, M R Clemens, D H Marjot

    Lancet (London, England)
    |August 10, 1985
    PubMed
    Summary

    Chronic alcoholism significantly elevates a specific free-radical marker in blood. This marker, phospholipid-esterified 9,11 linoleic acid isomer, returns to normal levels within days of alcohol withdrawal.

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    Area of Science:

    • Biochemistry
    • Clinical Medicine
    • Toxicology

    Background:

    • Free radicals are implicated in various disease states.
    • Identifying specific markers of oxidative stress is crucial for understanding disease mechanisms.
    • Chronic alcoholism is associated with significant physiological changes.

    Purpose of the Study:

    • To investigate free-radical activity in chronic alcoholics.
    • To identify and quantify a specific free-radical marker in human serum.
    • To compare marker levels in alcoholics with various control groups.

    Main Methods:

    • Serum samples were collected from 66 chronic alcoholics post-withdrawal and during follow-up.
    • Control groups included normal subjects, liver disease patients, and others.

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  • Levels of phospholipid-esterified 9,11 linoleic acid isomer were measured.

    • Main Results:

    • 82% of chronic alcoholics showed elevated levels of the linoleic acid isomer within 24 hours of last drink.
    • Marker levels normalized within 2-4 days post-withdrawal.
    • No significant increase was observed in normal controls after acute alcohol intake.

    Conclusions:

    • Chronic alcoholism appears to induce a specific alcohol-activated detoxifying mechanism.
    • This mechanism is associated with significantly increased free-radical activity.
    • The identified isomer serves as a reliable marker for alcohol-induced oxidative stress.