Related Experiment Video

Updated: Feb 28, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.7K

Microparticles in acute coronary syndrome

Chrysostomos A Mavroudis1, Despina Eleftheriou2, Ying Hong2

  • 1Department of Cardiology, Royal Free Hospital, Royal Free London Foundation Trust, United Kingdom.

Thrombosis Research
|June 19, 2017
PubMed
Abstract

Insights

Elevated microparticles (MPs) in coronary arteries and blood, particularly platelet MPs, correlate with Troponin T in acute coronary syndrome (ACS) patients, suggesting a role in disease. This highlights MPs as potential biomarkers in ACS.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • Cell-derived microparticles (MPs) are increasingly implicated in the pathophysiology of acute coronary syndrome (ACS).
  • Understanding the role of MPs in ACS is crucial for developing new diagnostic and therapeutic strategies.
  • This study investigates the relationship between coronary and systemic MP levels in ACS patients.

Purpose of the Study:

  • To explore the relationship between coronary and systemic microparticle (MP) levels in patients with acute coronary syndrome (ACS).
  • To investigate the correlation between MPs, inflammatory markers, and Troponin T in ACS patients.
  • To assess the potential pathogenic role of MPs in ACS.

Main Methods:

  • Flow cytometry was used to measure AnnexinV+MPs (AnV+MPs) and activated platelet-monocyte aggregates (PMA) in 37 ACS patients and 11 stable angina (SA) controls.
  • Measurements were taken from the right atrium (RA) and culprit coronary artery (CO) distal to the lesion.
  • Assays for high-sensitivity C-reactive protein (CRP), IL-6, TNF-α, serum amyloid A (SAA), and Troponin T were performed.

Main Results:

  • Total and cell-specific AnV+MP expression were significantly higher in ACS patients compared to controls, with elevated levels in both CO and RA.
  • Platelet activation positively correlated with Troponin T and platelet MPs in both CO and RA of ACS patients (r=0.4 for both).
  • No significant differences in inflammatory marker levels were observed between ACS and SA groups.

Conclusions:

  • Elevated coronary and systemic MP levels in ACS patients suggest a pathogenic role.
  • The positive correlation between platelet activation, Troponin T, and platelet MPs further supports the involvement of MPs in ACS.
  • MPs may serve as valuable biomarkers in the context of acute coronary syndrome.
Keywords:
Acute coronary syndromeInflammationMicroparticlesMyocardial necrosisPlatelet activation

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K
Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.5K

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
567
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.3K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
338
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
347
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
817
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
419