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Related Concept Videos

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Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
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Age at menarche and lung function: a Mendelian randomization study.

Dipender Gill1,2, Nuala A Sheehan3, Matthias Wielscher4

  • 1Department of Clinical Pharmacology and Therapeutics, Imperial College London, Hammersmith Hospital, London, UK.

European Journal of Epidemiology
|June 19, 2017
PubMed
Summary
This summary is machine-generated.

Earlier age at menarche is linked to reduced adult lung function, specifically restrictive lung impairment. However, a short-term post-pubertal benefit may precede this detrimental effect in women.

Keywords:
FEV1/FVCFVCLung functionMenarcheMendelian randomizationPuberty

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Area of Science:

  • Reproductive Health
  • Pulmonary Medicine
  • Genetics

Background:

  • Earlier menarche is associated with childhood factors and environmental exposures.
  • Observational studies suggest detrimental effects of early menarche on adult lung function, but confounding is a concern.

Purpose of the Study:

  • To investigate the causal effect of age at menarche on lung function using Mendelian randomization.
  • To assess the impact on restrictive lung impairment (FVC) and airway obstruction (FEV1/FVC) in adults and adolescents.

Main Methods:

  • Mendelian randomization analysis using genetic variants as proxies for age at menarche.
  • Derived SNP-age at menarche associations from a large genome-wide meta-analysis.
  • Meta-analyzed SNP-lung function estimates from adult women and adolescent girls, with sensitivity analyses for pleiotropy.

Main Results:

  • In adult women, increased age at menarche was associated with higher forced vital capacity (FVC), indicating less restrictive lung impairment.
  • In adolescent girls, an earlier age at menarche was associated with lower FVC, suggesting a potential short-term benefit.
  • No significant effect of age at menarche on airway obstruction (FEV1/FVC) was observed in either group.

Conclusions:

  • Mendelian randomization supports an association between earlier menarche and reduced adult lung function (restrictive impairment).
  • A potential short-term post-pubertal benefit in lung function may precede the long-term detrimental effect.
  • The findings suggest pubertal timing, not just menarche, may influence lung function generally.