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Emerging biomarkers of chronic kidney disease in children

Jason H Greenberg1,2, Aadil Kakajiwala3, Chirag R Parikh4,5,6

  • 1Department of Pediatrics, Section of Nephrology, Yale University School of Medicine, New Haven, CT, 06510, USA. jason.greenberg@yale.edu.

Pediatric Nephrology (Berlin, Germany)
|June 19, 2017
PubMed

Insights

This review explores 12 novel biomarkers for chronic kidney disease (CKD) to predict disease progression and improve patient management. Research highlights the need for more pediatric studies on these CKD biomarkers.

Area of Science:

  • Nephrology
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) is a major public health issue with significant morbidity.
  • Current methods like serum creatinine and proteinuria have limitations in predicting CKD progression.
  • Novel biomarkers are needed to enhance prediction and patient management.

Purpose of the Study:

  • To review findings on 12 candidate plasma and urine biomarkers for CKD.
  • To explore their association with CKD progression and pathophysiologic processes.
  • To identify biomarkers for improved clinical trial enrollment and patient care.

Main Methods:

  • Literature review of existing research on CKD biomarkers.
  • Analysis of 12 candidate plasma and urine biomarkers.
  • Exploration of pathophysiologic pathways including tubulointerstitial injury, inflammation, repair, and fibrosis.

Main Results:

  • Salient findings on 12 candidate biomarkers associated with CKD are discussed.
  • Biomarkers potentially classify pathophysiologic processes in CKD progression.
  • Significant gap identified in pediatric research for CKD progression biomarkers.

Conclusions:

  • Novel biomarkers show promise for predicting CKD progression and timing interventions.
  • An optimal biomarker panel could enhance current predictive methods and clinical trial enrichment.
  • Further longitudinal studies, especially in pediatrics, are crucial for validating these biomarkers for clinical use.

Keywords:
BiomarkerCKDCKD progressionESRDPediatrics

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