Related Experiment Video

Updated: Feb 28, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

8.4K

Protein Tyrosine Signaling and its Potential Therapeutic Implications in Carcinogenesis

Mihwa Kim1, Minwoo Baek1, Dae Joon Kim1

  • 1Department of Biomedical Sciences, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA.

Current Pharmaceutical Design
|June 20, 2017
PubMed

Insights

Protein tyrosine kinases (PTKs) and phosphatases (PTPs) are key regulators of cell signaling in epithelial cancers. Targeting these pathways offers promising strategies for cancer prevention and treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Protein tyrosine phosphorylation is a critical signaling mechanism in epithelial carcinogenesis.
  • Protein tyrosine kinases (PTKs) regulate cellular processes like growth and motility via pathways such as STAT3, AKT, and MAPK.
  • Dysregulation of PTKs and their downstream pathways contributes to epithelial cancer development.

Purpose of the Study:

  • To explore the role of PTKs and PTPs in epithelial carcinogenesis.
  • To highlight PTKs as attractive targets for cancer prevention and treatment.
  • To discuss the dual role of PTPs as tumor suppressors or promoters.

Main Methods:

  • Review of current literature on PTK and PTP signaling in cancer.
  • Analysis of signaling pathways regulated by PTKs (STAT3, AKT, MAPK).
  • Examination of the substrate-dependent functions of PTPs.

Main Results:

  • PTKs are implicated in cancer development through mutations or prolonged activation.
  • PTK inhibitors are utilized in treating cancers with high PTK expression.
  • PTPs, the counterparts of PTKs, modulate phosphotyrosine signaling and can act as tumor suppressors or promoters.

Conclusions:

  • Both PTK and PTP signaling pathways represent potential therapeutic targets for cancer prevention and treatment.
  • Understanding the specific roles of PTPs based on their substrates is crucial for therapeutic development.
  • Targeting PTKs and PTPs offers a dual approach for cancer therapy.
Keywords:
AKTCarcinogenesisEGFRIGF-1RPTKPTPSTAT3tyrosine phosphorylation

More Related Videos

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

6.7K
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

584

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.5K
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
19.9K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K