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Mesenchymal Stem Cell-based Therapy as a New Horizon for Kidney Injuries
Amaneh Mohammadi Roushandeh1, Marzie Bahadori2, Mehryar Habibi Roudkenar3
1Anatomical Sciences Department, Medicine Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract:
Today, the prevalence of kidney diseases is increasing around the world, but there has still been no effective medical treatment. The therapeutic choices are confined to supportive cares and preventive strategies. Currently, mesenchymal stem cells (MSCs)-based cell therapy was proposed for the treatment of kidney injuries. However, after the transplantation of MSCs, they are exposed to masses of cytotoxic factors involving an inflammatory cytokine storm, a nutritionally-poor hypoxic environment and oxidative stresses that finally lead to minimize the efficacy of MSCs based cell therapy. Therefore, several innovative strategies were developed in order to potentiate MSCs to withstand the unfavorable microenvironments of the injured kidney tissues and improve their therapeutic potentials. This review aims to introduce MSCs as a new modality in the treatment of renal failure. Here, we discuss the clinical trials of MSCs-based therapy in kidney diseases as well as the in vivo studies dealing with MSCs application in kidney injuries mainly from the proliferation, differentiation, migration and survival points of view. The obstacles and challenges of this new modality in kidney injuries are also discussed.
Insights
Mesenchymal stem cells (MSCs) show promise for treating kidney disease, but face challenges in harsh kidney environments. Strategies are being developed to enhance MSC efficacy for renal failure therapy.
Area of Science:
- Regenerative Medicine
- Nephrology
- Cell Therapy
Background:
- Kidney diseases are globally increasing with limited effective treatments.
- Current therapies focus on supportive care and prevention.
- Mesenchymal stem cells (MSCs) offer a potential cell-based therapy for kidney injuries.
Purpose of the Study:
- To review Mesenchymal stem cells (MSCs) as a therapeutic option for renal failure.
- To discuss clinical trials and in vivo studies of MSCs in kidney diseases.
- To explore strategies for enhancing MSCs' therapeutic potential in kidney injury.
Main Methods:
- Review of clinical trials involving MSCs for kidney diseases.
- Analysis of in vivo studies on MSC application in kidney injuries.
- Examination of MSC proliferation, differentiation, migration, and survival.
Main Results:
- MSCs face cytotoxic factors (inflammation, hypoxia, oxidative stress) in injured kidneys, limiting efficacy.
- Innovative strategies are being developed to improve MSC survival and function.
- Studies investigate MSCs' potential to regenerate kidney tissue.
Conclusions:
- Mesenchymal stem cells (MSCs) represent a promising, novel approach for treating renal failure.
- Overcoming the challenges of the kidney microenvironment is crucial for successful MSC therapy.
- Further research and clinical trials are needed to optimize MSC-based treatments for kidney diseases.
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