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TREX1 Cuts Down on Cancer Immunogenicity

Takahiro Yamazaki1, Lorenzo Galluzzi2

  • 1Department of Radiation Oncology, Weill Cornell Medical College, 10065 New York, NY, USA.

Trends in Cell Biology
|June 20, 2017
PubMed

Insights

Researchers found that the enzyme prime repair exonuclease 1 (TREX1) limits immune responses to radiation therapy. Targeting TREX1 may enhance cancer cell immunogenicity and improve radiation therapy effectiveness.

Area of Science:

  • Oncology
  • Immunology
  • Radiation Biology

Background:

  • Radiation therapy (RT) is a cornerstone of cancer treatment.
  • The immunogenicity of cancer cells influences RT efficacy.
  • Limited tumor immunogenicity can hinder treatment outcomes.
Keywords:
STINGabscopal effectcGAScheckpoint blockersimmunogenic cell deathtype I interferon

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