Corticosteroids in neurological disorders: The dark side.

Area of Science:

• Neurology
• Pharmacology
• Pathophysiology

Background:

• Corticosteroids are frequently prescribed across medical specialties, including neurology.
• Their use is supported by studies and expert consensus.
• Beyond known side effects, corticosteroids can trigger or exacerbate neurological conditions.

Purpose of the Study:

• To review the adverse neurological effects of corticosteroid therapy.
• To elucidate the pathophysiological mechanisms linking corticosteroids to neurological disorders.

Main Methods:

• Literature review of studies on corticosteroid-induced neurological complications.
• Analysis of proposed pathophysiological pathways.

Main Results:

• Corticosteroids are associated with a range of neurological adverse effects.
• Specific mechanisms include neuroinflammation, metabolic disturbances, and direct neurotoxicity.

Conclusions:

• Physicians should be aware of the potential for corticosteroids to induce or worsen neurological disorders.
• Understanding the mechanisms is crucial for mitigating these risks.