Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.4K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.4K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

41.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

430
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
430
Understanding Sleep01:11

Understanding Sleep

1.7K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.7K
Modeling in Therapy01:26

Modeling in Therapy

606
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
606

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[HYPNOSTRESS study: Interest of medical hypnosis in the evaluation of perceived stress and the experience of hospitalization in an internal medicine department].

La Revue de medecine interne·2024
Same author

Functioning and neurocognition in very early and early-life onset bipolar disorders: the moderating role of bipolar disorder type.

European child & adolescent psychiatry·2024
Same author

[Transbronchial lung cryobiopsy in interstitial lung diseases].

Revue des maladies respiratoires·2023
Same author

DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae.

DNA repair·2023
Same author

[Borderline personality disorder: state of knowledge and attitudes among french-speaking mental health professionnals].

L'Encephale·2022
Same author

Demographic, clinical, and service-use characteristics related to the clinician's recommendation to transition from child to adult mental health services.

Social psychiatry and psychiatric epidemiology·2022

Related Experiment Video

Updated: Feb 28, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

22.1K

Are circadian rhythms new pathways to understand Autism Spectrum Disorder?

M-M Geoffray1, A Nicolas2, M Speranza3

  • 1Department of Child and Adolescent Psychiatry, Centre Hospitalier le Vinatier, Lyon, France.

Journal of Physiology, Paris
|June 20, 2017
PubMed
Summary

Circadian rhythms, which regulate sleep-wake cycles, may play a role in Autism Spectrum Disorder (ASD) etiology. Disruptions in these biological rhythms and their associated genes could influence brain development and ASD susceptibility.

Keywords:
Autism Spectrum DisorderCircadian rhythmsSleep

More Related Videos

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.7K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K

Related Experiment Videos

Last Updated: Feb 28, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

22.1K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.7K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K

Area of Science:

  • Neurodevelopmental disorders
  • Chronobiology
  • Genetics

Background:

  • Autism Spectrum Disorder (ASD) is a common neurodevelopmental condition.
  • ASD results from complex gene-environment interactions affecting brain development.
  • Circadian rhythms govern physiological processes, including sleep-wake cycles, and are often disrupted in ASD, with associated low melatonin levels.

Purpose of the Study:

  • To explore the potential role of circadian rhythms in the etiology of Autism Spectrum Disorder.
  • To investigate the link between circadian rhythm disruptions and ASD.

Main Methods:

  • Review of existing literature on circadian rhythms, genetics, and ASD.
  • Analysis of the molecular mechanisms involving circadian clock genes (e.g., CLOCK, BMAL1) and clock-controlled genes (CCGs).

Main Results:

  • Circadian rhythm disruptions are frequently observed in individuals with ASD, often accompanied by sleep disturbances and altered melatonin levels.
  • Circadian rhythms are regulated by genetic feedback loops involving CLOCK and BMAL1, influencing daily gene expression patterns.
  • Some CCGs are implicated in synaptic function and have been associated with ASD susceptibility.
  • Emerging evidence suggests circadian rhythms influence critical brain development processes.

Conclusions:

  • Circadian rhythm dysregulation is a potential contributing factor to ASD etiology.
  • The molecular clock machinery and its downstream targets, including synaptic genes, represent promising avenues for understanding ASD pathogenesis.
  • Further research into the interplay between circadian biology and neurodevelopment is warranted for ASD.