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Lifelong dietary intervention does not affect hematopoietic stem cell function.

Seka Lazare1, Albertina Ausema1, Aaffien C Reijne2

  • 1European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands.

Experimental Hematology
|June 20, 2017
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Summary
This summary is machine-generated.

Lifelong caloric restriction or excess calorie intake did not prevent age-related functional decline in hematopoietic stem cells (HSCs). These dietary interventions failed to impact HSC aging, despite effects on bone marrow cellularity.

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Area of Science:

  • Gerontology
  • Hematology
  • Stem Cell Biology

Background:

  • Hematopoietic stem cells (HSCs) show significant functional decline with normal aging.
  • Caloric restriction (CR) is known to delay aging in various species.
  • The impact of long-term CR or excess caloric intake on HSCs remains unclear.

Purpose of the Study:

  • To investigate the effects of lifelong caloric restriction or excess caloric intake on HSC number and function.
  • To determine if dietary interventions can mitigate age-associated HSC dysfunction.

Main Methods:

  • Mice were subjected to lifelong caloric restriction or a high-fat diet.
  • HSC numbers and long-term repopulating function were assessed in aged mice.
  • Bone marrow cellularity was analyzed.

Main Results:

  • Caloric restriction prevented age-dependent increases in bone marrow cellularity.
  • Neither caloric restriction nor a lifelong high-fat diet prevented the functional decline of aged, long-term HSCs.
  • HSC function was not affected by lifelong high-fat diet.

Conclusions:

  • Lifelong caloric interventions do not prevent age-associated HSC functional decline.
  • Dietary strategies targeting caloric intake are insufficient to maintain HSC function during aging.