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Related Experiment Videos

A transposon-like element in human DNA.

K E Paulson, N Deka, C W Schmid

    Nature
    |July 25, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    Researchers identified a novel human transposable element with features of mobile genetic elements. This repetitive sequence, found in extrachromosomal DNA, exhibits characteristics of transposons, including flanking long terminal repeats and direct repeats.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Genomics

    Background:

    • Mobile genetic elements, including transposons, are known in various organisms but less characterized in mammals.
    • Mammalian transposon-like sequences are often retrovirus-related, suggesting other families may exist.
    • Transposons share common biochemical and structural features, aiding identification.

    Purpose of the Study:

    • To identify and characterize novel transposable elements within the human genome.
    • To investigate a specific repetitive human sequence for transposon-like features.

    Main Methods:

    • Structural analysis of a 2.3-kilobase (kb) repetitive human sequence.
    • Identification of flanking long terminal repeat (LTR)-like sequences and direct repeats.
    • Analysis of polyadenylated transcripts from HeLa cells for homology.

    Related Experiment Videos

  • Investigation of extrachromosomal DNA for element presence.

    • Main Results:

    • A 2.3 kb transposon-like element was identified with diagnostic features of transposable elements.
    • The element possesses two flanking 350-base pair (bp) LTR-like sequences (5' TG...CA 3') and is bounded by 5-bp direct repeats.
    • Homologous, discrete-length polyadenylated transcripts were detected in HeLa cells.
    • This transposon-like family is present in extrachromosomal circular DNA molecules.

    Conclusions:

    • The characterized human repetitive sequence exhibits multiple hallmarks of transposable elements.
    • This finding expands the known repertoire of mobile genetic elements in the human genome.
    • The presence in extrachromosomal DNA suggests potential mobility or unique replication mechanisms.