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TCR+CD3+CD4-CD8- effector T cells in psoriasis.

D Brandt1, M Sergon2, S Abraham3

  • 1Division of Pediatric Rheumatology and Immunology, Children's Hospital Dresden, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.

Clinical Immunology (Orlando, Fla.)
|June 20, 2017
PubMed
Summary

Double negative (DN) T cells in psoriasis patients show reduced gene methylation and increased PD-1 expression, infiltrating skin lesions. These findings offer insights into psoriasis pathophysiology and potential therapeutic targets.

Keywords:
Double negative T cellsEffector memory T cellsIFN-γPD-1Programmed death-1Psoriasis

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