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Gastrointestinal Motility Monitor GIMM
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5-HT causes splanchnic venodilation.

Bridget M Seitz1, Hakan S Orer2, Teresa Krieger-Burke1

  • 1Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; and.

American Journal of Physiology. Heart and Circulatory Physiology
|June 20, 2017
PubMed
Summary
This summary is machine-generated.

Serotonin (5-hydroxytryptamine) causes splanchnic venodilation via 5-HT7 receptors, leading to lower blood pressure. This study links in vitro relaxation to in vivo blood pressure reduction, highlighting the role of splanchnic veins in regulation.

Keywords:
SB-269970blood pressureimagingpharmacologyserotoninveins

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Area of Science:

  • Cardiovascular Physiology
  • Neuropharmacology
  • Vascular Biology

Background:

  • Serotonin (5-hydroxytryptamine, 5-HT) is known to affect blood vessels.
  • The role of specific serotonin receptor subtypes in splanchnic venous tone and blood pressure regulation requires further elucidation.

Purpose of the Study:

  • To investigate the hypothesis that serotonin induces 5-HT7 receptor-dependent splanchnic venodilation.
  • To determine the contribution of splanchnic venodilation to the blood pressure-lowering effects of chronic serotonin infusion.

Main Methods:

  • In vitro isometric tension studies on isolated rat veins (superior mesenteric vein, portal vein, inferior vena cava).
  • Western blot analysis to detect 5-HT7 receptor expression in venous tissues.
  • In vivo ultrasound imaging in rats to measure venous diameter changes during chronic 5-HT infusion.
  • Radiotelemetry to monitor arterial blood pressure in conscious rats.

Main Results:

  • Serotonin and a 5-HT1/7 agonist caused relaxation of isolated splanchnic veins (superior mesenteric and portal veins) and abdominal inferior vena cava, which was blocked by a 5-HT7 antagonist (SB-269970).
  • 5-HT7 receptor protein was detected in splanchnic veins but not in the thoracic vena cava.
  • In vivo, chronic 5-HT infusion increased splanchnic venous diameters and decreased arterial pressure.
  • Administration of SB-269970 prevented both the venodilation and the decrease in blood pressure during 5-HT infusion.

Conclusions:

  • Serotonin induces 5-HT7 receptor-dependent relaxation of splanchnic veins.
  • Splanchnic venodilation mediated by the 5-HT7 receptor contributes to the hypotensive effect of serotonin.
  • These findings support a role for splanchnic venodilation in the regulation of blood pressure.