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Anti-acne drugs in phase 1 and 2 clinical trials

Christos C Zouboulis1, Clio Dessinioti2, Fragkiski Tsatsou1

  • 1a Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center , Theodore Fontane Medical University of Brandenburg , Dessau , Germany.

Expert Opinion on Investigational Drugs
|June 20, 2017
PubMed
Abstract

Insights

New acne treatments are emerging due to antibiotic resistance and side effects of current therapies. Research focuses on novel topical and systemic agents targeting acne pathogenesis for better patient outcomes.

Area of Science:

  • Dermatology
  • Pharmacology
  • Clinical Trials

Background:

  • Acne treatment research lags behind etiological understanding.
  • Existing therapies face challenges like antibiotic resistance and isotretinoin teratogenicity.
  • Need for novel anti-acne agents with improved safety profiles is critical.

Purpose of the Study:

  • To review Phase 1 and 2 clinical trials for new acne treatments.
  • To identify emerging therapeutic strategies and compounds for acne vulgaris.

Main Methods:

  • Searched US National Institutes of Health and European Medicines Agency clinical trial databases.
  • Utilized keywords 'acne' and 'treatment' for trials registered up to January 6, 2017.

Main Results:

  • Most trials focus on topical agents with sebosuppressive, antimicrobial, or anti-inflammatory actions.
  • Investigated compounds include olumacostat glasaretil, cortexolone 17α-propionate, and stearoyl-CoA desaturase 1 inhibitors.
  • Systemic agents under study include finasteride, biologics, and leukotriene B4 inhibitors.

Conclusions:

  • Emerging acne treatments explore diverse mechanisms beyond traditional approaches.
  • Novel agents aim to overcome limitations of current acne therapies.
  • Continued research is vital for developing safer and more effective acne management strategies.
Keywords:
Acnedrug developmentinvestigational drugsphase 1phase 2

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