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The Value of Serum Complement C1q in the Diagnosis of Acute Ischemic Stroke
Insights
Serum complement C1q is an independent risk factor for acute ischemic stroke. Higher levels correlate with increased stroke severity, infarct size, and neurological impairment.
Area of Science:
- Neurology
- Immunology
Background:
- Investigated serum complement C1q levels in 154 acute ischemic stroke patients and 42 healthy controls.
- Examined the association between C1q levels and stroke risk and severity.
Purpose of the Study:
- To determine the relationship between serum complement C1q levels and acute ischemic stroke.
- To assess C1q as a risk factor and its correlation with stroke severity.
Main Methods:
- Serum C1q levels measured using immune transmission turbidity.
- Conditional logistic regression for risk factor analysis.
- National Institute of Health Stroke Scale for neurological impairment assessment.
Main Results:
- Elevated serum C1q levels observed in ischemic stroke patients compared to controls.
- Serum C1q identified as an independent pathogenic factor for cerebral infarction.
- C1q levels decreased with longer onset times but increased with larger infarct volumes.
Conclusions:
- Serum complement C1q is an independent risk factor for acute ischemic stroke.
- C1q levels are linked to stroke incidence, infarct size, and neurological deficits.
Background:
To investigate the relationship between the levels of serum complement C1q and the risk and severity of acute ischemic stroke, a total of 154 patients with acute ischemic stroke and 42 healthy volunteers as normal controls were enrolled in the present study.
Methods:
According to the onset time of stroke, patients were divided into three groups. Using an immune transmission turbidity method, the levels of serum complement C1q were detected to investigate the relationship between the level of serum complement C1q and the incidence and severity of acute ischemic stroke. The risk factors of these groups were calculated using a conditional logistic regression model. The assessment of neurological function impairment was carried out according to the National Institute of Health Stroke Scale. Then correlation anal- ysis was carried out between the level of serum complement C1q among patients with acute ischemic stroke and the degree of neurological function impairment.
Results:
The results showed that the level of serum complement C1q was higher in the ischemic stroke group than in the control group. Using a conditional logistic regression model it was discovered that serum complement C1q was the independent pathogenic factor of cerebral infarction. There also was a decreasing trend in the level of serum complement C1q with the extension of the onset time and an increasing trend in the level of serum complement C1q with the increase in the maximum diameter of infarction volume.
Conclusions:
Serum complement C1q is an independent risk factor for acute outbreak of ischemic stroke, whose level is closely related to the outbreak and infarct size and neurological function impairment.
