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Nutrients, neurotransmitters and infant behavior.

M W Yogman, S H Zeisel

    The American Journal of Clinical Nutrition
    |August 1, 1985
    PubMed
    Summary
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    Dietary tryptophan and insulin significantly impact infant sleep patterns by influencing brain serotonin synthesis. This suggests infant sleep behavior is a sensitive indicator of dietary effects on neurotransmitter levels.

    Area of Science:

    • Neuroscience
    • Developmental Psychology
    • Nutritional Science

    Background:

    • Dietary precursors, like tryptophan, influence brain neurotransmitter synthesis.
    • Insulin plays a crucial role in modulating these metabolic pathways.
    • Evidence suggests a link between adult sleep behavior and brain serotonin levels.

    Purpose of the Study:

    • To review the effects of dietary composition on neurotransmitter synthesis in newborns.
    • To assess the relationship between diet, serotonin levels, and newborn sleep behavior.
    • To investigate the influence of hyperinsulinemia on infant behavior and neurochemistry.

    Main Methods:

    • Review of studies on dietary precursors (tryptophan, amino acids) and serotonin synthesis.
    • Observational studies on newborn state behavior, diet, and sleep patterns.

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  • Analysis of plasma amino acid ratios during glucagon stimulation in infants with hyperinsulinemia.
  • Main Results:

    • Infants fed tryptophan exhibited quicker entry into active and quiet sleep compared to controls.
    • Newborns of diabetic mothers (indicating hyperinsulinemia) showed reduced alertness and motor performance.
    • Plasma amino acid profiles correlated with insulin level changes during stimulation tests.

    Conclusions:

    • Infant sleep behavior is a sensitive measure for studying dietary impacts on behavior.
    • Variations in serotonin levels likely modulate infant sleep and behavioral outcomes.
    • Maternal diabetes and resulting hyperinsulinemia can affect newborn neurobehavioral development.