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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Feb 28, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

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Pharyngeal amyloidomas: Variable appearance on imaging.

C A Prause1, Q Zhai1, S M Weindling1

  • 1Mayo Clinic Jacksonville, USA.

The Neuroradiology Journal
|June 20, 2017
PubMed
Summary
This summary is machine-generated.

Amyloidomas, rare protein deposits, can appear differently on head and neck imaging. Identifying these lesions aids in diagnosis and prognosis, especially for isolated cases.

Keywords:
Amyloidomasamyloidosesamyloidosishead and neckplasmacytoma

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Area of Science:

  • Medicine
  • Radiology
  • Pathology

Background:

  • Amyloidomas are uncommon tumoral deposits of misfolded proteins, associated with systemic amyloidosis or as isolated masses.
  • Focal amyloidomas generally have a favorable prognosis, unlike systemic forms of amyloidosis.
  • Accurate imaging identification of amyloidomas can guide diagnostic testing.

Observation:

  • Head and neck amyloidomas exhibit variable imaging features, often appearing T2 hypointense to iso-slightly hyperintense compared to muscle.
  • This study details two cases of pharyngeal submucosal amyloidomas with distinct imaging characteristics.
  • The variable appearance underscores the diagnostic challenge these rare lesions present.

Findings:

  • Amyloidomas can present with widely differing imaging appearances on diagnostic studies.
  • The size and specific imaging characteristics of amyloidomas can vary significantly.
  • Submucosal pharyngeal amyloidomas were observed in the presented cases.

Implications:

  • Recognizing the diverse imaging spectrum of amyloidomas is crucial for radiologists and clinicians.
  • Improved imaging recognition can lead to earlier and more accurate diagnosis of amyloidomas.
  • Further research into the imaging of rare amyloidomas can enhance understanding and patient management.