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Updated: Feb 28, 2026

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A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate

Yi-Ling Du1,2, Hai-Yan He2, Melanie A Higgins2

  • 1Institute of Pharmaceutical Biotechnology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Nature Chemical Biology
|June 20, 2017
PubMed
Summary

Researchers discovered a novel enzyme, KtzT, that catalyzes nitrogen-nitrogen (N-N) bond formation. This enzyme is crucial for synthesizing piperazate, a key component in nonribosomal peptides.

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